
– GLLC (Global Life Laboratory Corp.) Co-Founder
– CurXcel Corp. CEO/President
– Joh-Dar Corp. Co-Founder/Chief Science & Technology Officer
– Core Life Source, Inc. Founder/CEO
– Pezzuto, JM, DasGupta, TK, Kim, DSHL. Method and Composition for Selectively Inhibiting Melanoma. U.S. 6,225,353 (May 1, 2001).
– Zaneveld, LJD, Anderson Jr., A, Diao, XH, Young, Jr., PR, Waller, DP, Garg, S, Chany II, CJ, Kim, DSHL. Method for preventing sexually transmitted disease. U.S. 5,932,619 (Aug. 3, 1999).
– Pezzuto, JM, DasGupta, TK, Schmidt, ML, Kuzmanoff, KM, Ling-Indeck, L, Kim, DSHL. Method and composition for treating cancers. U.S. 5,962,527 (Oct. 5. 1999).
– Pezzuto, JM, DasGupta, TK, Kim, DSHL. Method and composition for selectively inhibiting melanoma. U.S. 5,869,535 (Feb. 9, 1999).
– Pezzuto, JM, Kim, DSHL. Methods of manufacturing betulinic acid. U.S. 5,804,575 (Sept. 8, 1998).
– Chang, Cj, Ashendel, C, Kim, DSHL. Selenophene antitumor agent (patent pending).
– Kim, DSHL. Methods of protecting brain cells from ß-amyloid induced Alzheimer’s disease (patent pending).
1. Freeman, F, Kim, DSHL, Rodriguez, E. The chemistry of 1,2-dithiins. Sulfur Reports 1989, 9, 207-256.
2. Freeman, F, Kim, DSHL. Preparation of 2-alkyl- and 2-aryl-5-amino-4-cyano-1,3-oxazoles. Tetrahedron Lett. 1989, 30, 2631-2632.
3. Freeman, F, Kim, DSHL. Preparation of (1E,3E)-4-amino-1-aryl-3-cyano-4-methoxy-2-azabutadienes. Synthesis 1989, 698-699.
4. Freeman, F, Kim, DSHL. Reaction of aminopropanedinitrile 4-methylbenzenesulfonate [aminomalononitrile p-toluenesulfonate (tosylate)] with aromatic aldehydes. J. Org. Chem. 1991, 56, 657-663.
5. Freeman, F, Kim, DSHL. Reaction of aminopropanedinitrile 4-methylbenzenesulfonate [aminomalononitrile p-toluenesulfonate (tosylate)] with isothiocyanates. J. Org. Chem. 1991, 56, 4645-4648.
6. Freeman, F, Kim, DSHL. Preparation of 1,4-diketones and their reactions with bis(trialkyltin) or bis(triphenyltin)sulfide and boron trichloride. J. Org. Chem. 1992, 57, 1722-1727.
7. Freeman, F, Kim, DSHL. Condensation reaction of (1E,3E)-3-amino-3-cyano-4-methoxy-1-phenyl-2-aza-butadiene and electrocyclizations of diazatrienes. J. Org. Chem. 1992, 57, 550-552.
8. Freeman, F, Kim, DSHL, Rodriguez, E. Synthesis of 4-propynyl-1-(5-ene-1,3-hexadiynyl)-1,3-cyclohexadiene and 4-(1-propynyl)-1-(4-(trimethylsilyl)-1,3-butadiynyl) -1,3-cyclohexadiene. J. Org. Chem. 1993, 58, 2317.
9. Freeman, F, Kim, DSHL. A facile synthesis of methyl (2Z,3E)-6-aryl-4,4-dicyano-5-aza-2,5-hexadienoates [(1E,4Z)-2-aza-1,4-pentadienes]. J. Org. Chem., 1993, 58, 6474.
10. Kim, DSHL, Koonchanok, N, Geahlen, RL, Ashendel, CL, Chang, Cj. Structure activity relationship study of emodin derivatives based on the protein-tyrosine kinase and protein kinase C inhibitory activities and cytotoxicity. Natural Product Letters, 1997, 10, 173-180.
11. Zhang, LS, Lau, YK, Hong, RL, Kim, DSHL, Chang, Cj, Hung, MC. Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu induced cellular transformation and metastasis-associated properties. Proceedings of the Am. Assoc. for Cancer Research, 1997, 38, #3138.
12. Kim, DSHL, Freeman, F. Enethiol assisted [3,4] and [3,5] sigmatropic rearrangements during thionation of 2,3-diaroylbicyclo[2.2.1]hepta-5-enes with boron sulfide. Tetrahedron Lett. 1997, 38, 799-802.
13. Kim, DSHL, Chen, Z, Nguyen, van T, Pezzuto, JM, Qiu, S, Lu, ZZ. A concise semi-synthetic approach to betulinic acid from betulin. Synth. Commun., 1997, 27, 1607-1612.
14. Lin, Z, Raman, A, Kim, DSHL. Betulinic acid and betulin at up to 10 mM concentration have no inhibitory effects on Melan-A line. J. Pharm. Pharmacol. 1997, 49, Suppl. 4, 35.
15. Nguyen, vT, Kim, DSHL, Fong, HS, Soejarto, D, Tri, MV, Xuan, LT, Khanh, TK. Structure elucidation of two new triterpenoids from Ficus fistulosa., Phytochemistry, 1998, 50, 467-469.
16. Kim, DSHL, Ashendel, CL, Chang, Cj. Novel protein kinase C inhibitors: a-Terthiophene derivatives. Bioorg. Med. Chem. Lett. 1998, 8, 2695-2698.
17. Kim, DSHL, Pezzuto, JM, Pisha, E. Synthesis of betulinic acid derivatives with activity against human melanoma. Bioorg. Med. Chem. Lett. 1998, 8, 1707-1712.
18. Zhang, L, Lau, YK, Xi, L, Hong, RL, Kim, DSHL, Chen, CF, Hortobagyi, GN, Chang, Cj, Hung, MC. Tyrosine kinase inhibitors, emodin and its derivatives repress HER-2/neu-induced cellular transformation and metastasis-associated properties. Oncogene 1998, 16, 2855-2863.
19. Kim, NC, Kinghorn, AD, Kim, DSHL. Semisynthesis of abrusoside A methyl ester. Organic Letters 1999, 1, 223-224.
– University of Califonia at Irvine BA and Ph. D (Biology & Organic Chemistry)
– Perdue University Postdoctoral, New Drug Discovery, Medicinal Chemistry and Pharmacognosy
– Ex. Professor, University of Illinois at Chicago (UIC). , Department of Medicinal Chemistry and Pharmacognosy, the Program for Collaborative Research in Pharmaceutical Sciences (PCRPS), College of Pharmacy
– Bioorganic and Medicinal Chemistry
– Journal of Organic Chemistry
– Organic Letter
– Journal of Agricultural and Food Chemistry